Mdm2
Mdm2
Mdm2 (pronounced "em-dee-em-two"), also known as Mouse double minute 2 homolog, is a protein that in humans is encoded by the MDM2 gene.
Pronunciation
Mdm2 is pronounced as "em-dee-em-two".
Etymology
The term "Mdm2" is derived from the phrase "Mouse double minute 2 homolog". The name was given due to its discovery in mouse cells, where it was observed to be amplified in double minute chromosomes.
Function
Mdm2 is an important protein that plays a crucial role in cell cycle regulation and apoptosis, preventing cellular apoptosis or programmed cell death. It is best known for its interaction with p53, a tumor suppressor protein. Mdm2 can inhibit p53's activity and mediate its degradation.
Clinical significance
Overexpression of Mdm2 in humans can lead to excessive inactivation of p53, diminishing its tumor suppressor function and potentially leading to the formation of tumors. This has been observed in a variety of cancer types, making Mdm2 a target for cancer therapy.
Related terms
- p53: A tumor suppressor protein that is regulated by Mdm2.
- Apoptosis: A form of programmed cell death that Mdm2 helps to prevent.
- Cancer: A disease characterized by uncontrolled cell growth, in which Mdm2 can play a role if overexpressed.
External links
- Medical encyclopedia article on Mdm2
- Wikipedia's article - Mdm2
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