Methestrol
Methestrol
Methestrol (pronunciation: meh-thes-trol), also known as promethestrol, is a synthetic, nonsteroidal estrogen that was formerly used for estrogen replacement therapy. It is a diphenol that is structurally related to diethylstilbestrol.
Etymology
The term "Methestrol" is derived from the words "methyl", referring to its methyl groups, and "estrol", a variant of "estrogen", the class of hormones it mimics.
Usage
Methestrol was primarily used in the treatment of menopausal and postmenopausal disorders. However, it is no longer marketed due to its association with an increased risk of endometrial cancer and other adverse effects.
Pharmacology
Methestrol, like other synthetic estrogens, binds to and activates estrogen receptors in various tissues in the body. It has been found to have relatively high estrogenic potency.
Related Terms
- Estrogen: A group of steroid hormones that promote the development and maintenance of female characteristics of the body.
- Diphenol: A type of phenol that contains two hydroxyl groups.
- Diethylstilbestrol: A synthetic nonsteroidal estrogen that was formerly used in the prevention of miscarriage and premature delivery in pregnant women.
- Endometrial cancer: A type of cancer that arises from the lining of the uterus, the endometrium.
- Estrogen receptors: A group of proteins found inside cells, which are activated by the hormone estrogen.
External links
- Medical encyclopedia article on Methestrol
- Wikipedia's article - Methestrol
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