Mixed lineage kinase domain like pseudokinase
Mixed lineage kinase domain like pseudokinase (MLKL) is a protein that in humans is encoded by the MLKL gene. The pronunciation of this term is /ˈmɪkst ˈlɪniɪdʒ ˈkaɪnˈdeɪm ˈlaɪk ˌsjuːdəʊˈkaɪnəs/. The etymology of the term is derived from the combination of the words "mixed lineage kinase" and "pseudokinase", indicating its function and classification.
Function
The MLKL gene provides instructions for making a protein that plays a key role in a form of programmed cell death called necroptosis. This process is activated as a defense mechanism against viral, bacterial, or fungal infections.
Structure
The MLKL protein contains a pseudokinase domain, which is similar in structure to kinase enzymes but lacks the ability to add a phosphate group to other proteins. Instead, the pseudokinase domain of MLKL binds to other proteins and changes shape, which triggers necroptosis.
Clinical significance
Mutations in the MLKL gene have been associated with several diseases, including neurodegenerative diseases and cancer. Inhibitors of MLKL are being investigated as potential treatments for these conditions.
Related terms
See also
External links
- Medical encyclopedia article on Mixed lineage kinase domain like pseudokinase
- Wikipedia's article - Mixed lineage kinase domain like pseudokinase
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