Nedaplatin

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Nedaplatin (pronounced: ne-dap-la-tin) is a platinum-based chemotherapy drug used primarily in the treatment of various types of cancer. It is a second-generation platinum compound with a broad spectrum of antitumor activity.

Etymology

The term "Nedaplatin" is derived from the chemical name "cis-diammine-glycolato-platinum", which is often abbreviated as "NDP". The prefix "Neda-" is derived from the abbreviation NDP, and "-platin" is a common suffix for platinum-based drugs.

Pharmacology

Nedaplatin is a platinum coordination complex that is activated intracellularly to form reactive platinum complexes that bind to nucleophilic groups such as GC-rich sites in DNA, thereby inducing DNA cross-links and inhibiting DNA synthesis and function, resulting in cell death.

Clinical Use

Nedaplatin is used in the treatment of various types of cancers, including lung cancer, esophageal cancer, cervical cancer, and head and neck cancer. It is often used in combination with other chemotherapy drugs.

Side Effects

Like other chemotherapy drugs, Nedaplatin can cause a range of side effects, including nausea, vomiting, anemia, and neutropenia. It is also known to cause nephrotoxicity (kidney damage) and ototoxicity (hearing damage).

Related Terms

  • Cisplatin: A first-generation platinum-based chemotherapy drug.
  • Carboplatin: Another second-generation platinum-based chemotherapy drug.
  • Oxaliplatin: A third-generation platinum-based chemotherapy drug.

External links

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