Nikolsky's sign
Nikolsky's sign (pronunciation: ni-KOL-skee's sign) is a clinical dermatological sign, named after the Russian dermatologist Pyotr Vasilyevich Nikolsky.
Etymology
The term is named after Pyotr Vasilyevich Nikolsky, a Russian dermatologist who first described the sign in 1896.
Definition
Nikolsky's sign refers to the ability to elicit blistering of the skin by applying gentle lateral pressure. It is a clinical sign indicative of certain skin conditions, most notably Pemphigus Vulgaris and Stevens-Johnson Syndrome.
Clinical Significance
A positive Nikolsky's sign is typically associated with diseases that cause a weakening of the epidermis, the outermost layer of the skin. This includes conditions such as Pemphigus Vulgaris, Stevens-Johnson Syndrome, and Toxic Epidermal Necrolysis (TEN). The sign is used as a diagnostic tool to help identify these conditions.
Related Terms
- Pemphigus Vulgaris: An autoimmune blistering disease that causes blisters on the skin and mucous membranes.
- Stevens-Johnson Syndrome: A rare, serious disorder of the skin and mucous membranes, usually a reaction to a medication or an infection.
- Toxic Epidermal Necrolysis: A potentially life-threatening dermatological condition that is usually caused by a reaction to drugs.
See Also
External links
- Medical encyclopedia article on Nikolsky's sign
- Wikipedia's article - Nikolsky's sign
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