Noncompetitive
Noncompetitive
Noncompetitive (pronunciation: non-kom-pi-ti-tiv) is a term often used in the field of Pharmacology and Biochemistry to describe a type of enzyme inhibitor that does not compete with the substrate for the enzyme's active site.
Etymology
The term "noncompetitive" is derived from the English words "non-", meaning not, and "competitive", which refers to competition. In this context, it refers to an inhibitor that does not compete with the substrate for the enzyme's active site.
Definition
In Pharmacology, a noncompetitive inhibitor is a type of enzyme inhibitor that binds to an enzyme at a site different from the active site of the enzyme. This binding changes the shape of the enzyme and prevents it from binding to its substrate, thus inhibiting its activity. Unlike competitive inhibitors, noncompetitive inhibitors can bind to the enzyme whether the substrate is attached or not.
Related Terms
- Enzyme Inhibition: A process in which a molecule (an inhibitor) binds to enzymes and decreases their activity.
- Active Site: The region of an enzyme where substrate molecules bind and undergo a chemical reaction.
- Substrate: A molecule upon which an enzyme acts.
- Enzyme: Proteins that act as biological catalysts (biocatalysts).
- Competitive Inhibition: A form of enzyme inhibition where binding of the inhibitor to the active site on the enzyme prevents binding of the substrate.
External links
- Medical encyclopedia article on Noncompetitive
- Wikipedia's article - Noncompetitive
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