Norpipanone
Norpipanone
Norpipanone (pronunciation: nor-pi-pan-one) is a potent opioid analgesic drug that is structurally related to methadone. It was developed in the 1940s during research into analogues of pethidine and was assessed by the United Nations Office on Drugs and Crime but was not widely adopted and remains little known.
Etymology
The term "Norpipanone" is derived from the chemical structure of the drug, which is a piperidine derivative. The prefix "nor" is used in organic chemistry to denote a molecule that is a demethylated derivative of a parent compound, in this case, pipanone.
Pharmacology
Norpipanone is a potent mu-opioid receptor agonist. It has similar effects to other opioids, including analgesia, sedation, and respiratory depression. However, it is not widely used due to its potential for dependence and addiction.
Related Terms
- Opioid: A class of drugs that include the illegal drug heroin, synthetic opioids such as fentanyl, and pain relievers available legally by prescription, such as oxycodone (OxyContin®), hydrocodone (Vicodin®), codeine, morphine, and many others.
- Methadone: A synthetic opioid used for opioid maintenance therapy in opioid dependence and for chronic pain management.
- Pethidine: Also known as meperidine and sold under the brand name Demerol among others, is a synthetic opioid pain medication of the phenylpiperidine class.
- Mu-opioid receptor: A class of opioid receptors with high affinity for enkephalins and beta-endorphin but low affinity for dynorphins. They are also referred to as μ (mu) opioid peptide (MOP) receptors.
External links
- Medical encyclopedia article on Norpipanone
- Wikipedia's article - Norpipanone
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