Information about Nystatin
Nystatin is a topical and oral antifungal agent with activity against many species of yeast and candida albicans, which is used largely to treat skin and oropharyngeal candidiasis.
Liver safety of Nystatin
Nystatin is not absorbed orally and has not been linked to drug induced liver injury.
Mechanism of action of Nystatin
Nystatin (nye stat' in) is a polyene macrolide antibiotic that acts by binding to sterols in the plasma membranes of fungi causing the cells to leak, eventually leading to fungal cell death. Nystatin is indicated for the treatment of yeast and candidal infections of the skin, mucous membranes and gastrointestinal tract. It is not absorbed orally and thus not indicated for invasive fungal infections.
FDA approval information for Nystatin
Nystatin was approved by the FDA in 1971 and is currently widely used in the treatment of superficial yeast infections and candida infections of the skin, mucous membranes and gastrointestinal tract, including oropharyngeal candidiasis.
Dosage and administration for Nystatin
Nystatin is available in multiple forms such as tablets, troches, powder for suspension, creams and ointments and varying concentrations which are usually measured in units. Nystatin is available in generic forms and under brand names such as Mycostatin, Nilstat, Nystat and Nystop. The recommended dose for oropharyngeal candidiasis is 500,000 to 1,000,000 units 3 to 5 times daily as oral suspension or tablets (dissolved in the mouth) for 1 to 2 weeks.
Side effects of Nystatin
The following drugs are antifungal agents:
- Amphotericin B