O6-benzylguanine
O6-benzylguanine
O6-benzylguanine (pronunciation: O six benzyl guanine) is a synthetic derivative of the nucleoside guanine. It is used as a biochemical tool in the study of DNA repair mechanisms.
Etymology
The term "O6-benzylguanine" is derived from its chemical structure. The "O6" refers to the oxygen atom at the 6th position of the guanine molecule, and "benzyl" refers to the benzyl group that is attached to this oxygen atom.
Function
O6-benzylguanine acts as a potent inhibitor of the DNA repair protein O6-alkylguanine-DNA alkyltransferase (AGT). By inhibiting AGT, O6-benzylguanine can increase the effectiveness of certain chemotherapeutic agents that damage DNA.
Related Terms
- Guanine: One of the four main nucleobases found in the nucleic acids DNA and RNA.
- DNA repair: The collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome.
- O6-alkylguanine-DNA alkyltransferase (AGT): A protein that repairs DNA damage caused by alkylation.
See Also
External links
- Medical encyclopedia article on O6-benzylguanine
- Wikipedia's article - O6-benzylguanine
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