WikiMD is world's largest health encyclopedia with
28,557 pages, 3,991,640 edits & 34,290,934 views.
Osimertinib
Information about Osimertinib
Osimertinib is a small molecule tyrosine kinase receptor inhibitor and antineoplastic agent that is used in the therapy of selected forms of advanced non-small cell lung cancer (NSCLC).
Liver safety of Osimertinib
Osimertinib is associated with a moderate rate of serum aminotransferase elevations during therapy and rare instances of clinically apparent acute liver injury.
Mechanism of action of Osimertinib
Osimertinib (oh" sim er' ti nib) is a small molecule tyrosine kinase receptor inhibitor with potent activity against the epidermal growth factor receptor (EGFR) that is rearranged and mutated in selected cancers including approximately 5% of non-small cell lung cancer (NSCLC). The mutated, rearranged EGFR promotes unregulated cell growth and proliferation, and inhibition of its activity can result in death of cells that overexpress the receptor. Osimertinib has been found to inhibit mutated EGFR in cell culture and, in several clinical trials, was found to induce objective responses in a proportion of patients with advanced EGFR mutated (T790M) NSCLC.
FDA approval information for Osimertinib
Osimertinib received accelerated approval for use refractory, EGFR T790M-positive NSCLC in the United States in 2015. Osimertinib is available in tablets of 40 and 80 mg under the brand name Tagrisso.
Dosage and administration for Osimertinib
The recommended initial dose is 80 mg once daily, continued until progressive disease or intolerable toxicity occurs.
Side effects of Osimertinib
Side effects are common and include diarrhea, rash, dry skin and nail toxicity. Uncommon, but potentially severe side effects include interstitial lung disease, prolongation of the QTc interval, cardiomyopathy and embryo-fetal toxicity.
Alphabetic list of antineoplastic agents - 0-9 - A1 - A2 - A3 - A4 - A5 -A6 - B - C - D - E - F - G - H - I - JK - L - M - NO - PQ - R - S - T - UVW - XYZ
Cost and Coupons - Osimertinib
- GoodRx compare cost & coupons for Osimertinib
- Find the lowest cost of Osimertinib
- Search for Coupons for Osimertinib
Reviews for Osimertinib
Learn more about Osimertinib
Latest research (Pubmed)
External links
WikiMD needs you!
This WikiMD article Osimertinib is a stub.
If you are a healthcare professional familiar with the topic Osimertinib, or
A subject matter expert or authority on Osimertinib, you can help us.
About | Mission | Paid editors welcome!
| Osimertinib is part of WikiMD's Physician reviewed^ articles available 4free, 4all, 4ever! |
|---|
| Medicine: Health - Encyclopedia - Topics - Diseases - Cancer - Rare diseases - Random Page Navigation: Drugs - Wellness - Obesity - Diet - Ketogenic diet - W8MD weight loss diet - Editors: Recently Edited Pages - Alphabetical Order - Sponsors - USMLE The content on or accessible through WikiMD is for informational purposes only. WikiMD is not a substitute for professional medical advice. ^See full Disclaimers |
 Ad. Tired of being overweight?. W8MD's insurance Weight loss program can HELP* |
