Passenger virus

From WikiMD
Jump to navigation Jump to search

A passenger virus is a virus that is frequently found in samples from diseased tissue, such as tumours, but does not contribute to causing the disease.

Experimental demonstration of passenger status

Proving that a virus has no causative role can be difficult. Although none of the following signs is definitive, evidence that a virus found in diseased tissue is a passenger rather than a causative agent includes:

  • injection of the virus into healthy animals without causing disease;
  • the absence of the virus at the earliest stages of the disease;
  • curing the viral infection using antiviral drugs or vaccination with no effect on the course of the disease.


A well-established example is lactate dehydrogenase virus, which is often found in mouse tumours.[1] GB virus C and Chandipura virus are possible examples in humans.[2][3] It has also been suggested that a virus related to Alcelaphine herpesvirus 1 is a passenger virus that, unlike AHV1 itself, doesn't cause bovine malignant catarrhal fever.[4] The discredited Duesberg hypothesis posits that HIV is a passenger virus in the etiology of AIDS.[5]


  1. Mongini PK, Rosenberg LT. (1976) Inhibition of lymphocyte trapping by a passenger virus in murine ascitic tumors: characterization of lactic dehydrogenase virus (LDV) as the inhibitory component and analysis of the mechanism of inhibition. J Exp Med 143: 100–113 (PMID 1244415) (full text)
  2. Mphahlele MJ, Lau GK, Carman WF. (1998) HGV: the identification, biology and prevalence of an orphan virus. Liver 18: 143–155 (PMID 9716223)
  3. Potharaju NR, Potharaju AK (2006) Is Chandipura virus an emerging human pathogen? Arch Dis Child 91: 279–280 (PMID 16492900) (full text)
  4. Metzler, Alfred E (January 1991). "The malignant catarrhal fever complex". Comparative Immunology, Microbiology and Infectious Diseases. 14 (2): 107–124. doi:10.1016/0147-9571(91)90125-W.
  5. Duesberg P, Rasnick D. (1998) The AIDS dilemma: drug diseases blamed on a passenger virus. Genetica 104: 85–132 (doi:10.1023/A:1003405220186 PMID 10220905)


Help WikiMD

Find something you can improve? Join WikiMD as an an editor and help improve this page or others.

Apple bitten.svg

WikiMD is a free medical encyclopedia and wellnesspedia moderated by medical professionals.Portions of content adapted from Wikipedias article on Passenger virus licensed under GNU FDL.

W8MD weight loss logo

Ad. Tired of being overweight?. W8MD's insurance Weight loss program can HELP*

Quick links: Medicine Portal | Encyclopedia‏‎‏‎ | Gray's Anatomy‏‎ | Topics‏‎ |‏‎ Diseases‏‎ | Drugs | Wellness | Obesity‏‎ | Metabolic syndrome | Weight loss*
Disclaimer: The entire contents of WIKIMD.ORG are for informational purposes only and do not render medical advice or professional services. If you have a medical emergency, you should CALL 911 immediately! Given the nature of the wiki, the information provided may not be accurate, misleading and or incorrect. Use the information on this wiki at your own risk! See full Disclaimer.
Link to this page: <a href="">Passenger virus</a>

  • Individual results may vary for weight loss from our sponsors.