Passenger virus

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A passenger virus is a virus that is frequently found in samples from diseased tissue, such as tumours, but does not contribute to causing the disease.

Experimental demonstration of passenger status

Proving that a virus has no causative role can be difficult. Although none of the following signs is definitive, evidence that a virus found in diseased tissue is a passenger rather than a causative agent includes:

  • injection of the virus into healthy animals without causing disease;
  • the absence of the virus at the earliest stages of the disease;
  • curing the viral infection using antiviral drugs or vaccination with no effect on the course of the disease.

Examples

A well-established example is lactate dehydrogenase virus, which is often found in mouse tumours.[1] GB virus C and Chandipura virus are possible examples in humans.[2][3] It has also been suggested that a virus related to Alcelaphine herpesvirus 1 is a passenger virus that, unlike AHV1 itself, doesn't cause bovine malignant catarrhal fever.[4] The discredited Duesberg hypothesis posits that HIV is a passenger virus in the etiology of AIDS.[5]

References

Metabolic.jpg

Featured disease

Metabolic syndrome is a cluster of the most dangerous heart attack risk factors: diabetes and prediabetes, abdominal obesity, high triglycerides, low HDL cholesterol and high blood pressure.

Affects one in three adults

Affecting about 35 percent of all adults in the United States according to the CDC, metabolic syndrome contributes to weight gain, by causing a state of internal starvation called metabolic starvation. This in turn leads to increases hunger, sugar cravings and increased portions leading to overeating and weight gain.

Cause and effect misunderstood

Since we traditionally thought that the portion control (which in turn was attributed wrongly to poor will power)is the cause of weight gain, rather than the effect of this metabolic starvation, all our traditional ideas about cause and effect of obesity were not only wrong but lead to the “blame the victim” attitude when it comes to obesity.

Secret of weight gain revealed

Secret of weight gain, and metabolic syndrome revealed - it has been recently proven that metabolic syndrome, and the weight gain itself are caused by a process called insulin resistance. Check your metabolic syndrome risk using the free Metabolic syndrome meter. Watch this amazing Ted Med video that reveals the secret of weight loss - Stop blaming the victim for obesity


Template:Virus-stub Template:Medicine-stubPortions of content adapted from Wikipedias article on Passenger virus licensed under GNU FDL.

References

Metabolic.jpg

Featured disease

Metabolic syndrome is a cluster of the most dangerous heart attack risk factors: diabetes and prediabetes, abdominal obesity, high triglycerides, low HDL cholesterol and high blood pressure.

Affects one in three adults

Affecting about 35 percent of all adults in the United States according to the CDC, metabolic syndrome contributes to weight gain, by causing a state of internal starvation called metabolic starvation. This in turn leads to increases hunger, sugar cravings and increased portions leading to overeating and weight gain.

Cause and effect misunderstood

Since we traditionally thought that the portion control (which in turn was attributed wrongly to poor will power)is the cause of weight gain, rather than the effect of this metabolic starvation, all our traditional ideas about cause and effect of obesity were not only wrong but lead to the “blame the victim” attitude when it comes to obesity.

Secret of weight gain revealed

Secret of weight gain, and metabolic syndrome revealed - it has been recently proven that metabolic syndrome, and the weight gain itself are caused by a process called insulin resistance. Check your metabolic syndrome risk using the free Metabolic syndrome meter. Watch this amazing Ted Med video that reveals the secret of weight loss - Stop blaming the victim for obesity


  1. Mongini PK, Rosenberg LT. (1976) Inhibition of lymphocyte trapping by a passenger virus in murine ascitic tumors: characterization of lactic dehydrogenase virus (LDV) as the inhibitory component and analysis of the mechanism of inhibition. J Exp Med 143: 100–113 (PMID 1244415) (full text)
  2. Mphahlele MJ, Lau GK, Carman WF. (1998) HGV: the identification, biology and prevalence of an orphan virus. Liver 18: 143–155 (PMID 9716223)
  3. Potharaju NR, Potharaju AK (2006) Is Chandipura virus an emerging human pathogen? Arch Dis Child 91: 279–280 (PMID 16492900) (full text)
  4. Duesberg P, Rasnick D. (1998) The AIDS dilemma: drug diseases blamed on a passenger virus. Genetica 104: 85–132 (Template:DOI PMID 10220905)

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