Patlak plot
Patlak Plot
The Patlak plot (/ˈpætlæk plɒt/) is a graphical analysis technique frequently used in nuclear medicine and radiology to provide a quantitative measure of the irreversible uptake of a radiotracer in the body.
Etymology
The Patlak plot is named after its developer, Csaba Patlak, a biophysicist who introduced the method in the 1980s.
Definition
The Patlak plot is a linear graphical representation of the irreversible uptake of a radiotracer in the body over time. It is used to calculate the influx constant (Ki), which is a measure of the rate at which the tracer is taken up by the tissue.
Method
The Patlak plot is created by plotting the ratio of the concentration of the tracer in the tissue to the concentration of the tracer in the blood against the integral of the blood concentration over time. The slope of the line in the linear portion of the plot is equal to the influx constant (Ki).
Applications
The Patlak plot is used in a variety of medical imaging applications, including positron emission tomography (PET) and single-photon emission computed tomography (SPECT). It is particularly useful in studies of the brain, where it can be used to measure the uptake of glucose or other substances.
Related Terms
- Radiotracer
- Nuclear medicine
- Radiology
- Positron emission tomography
- Single-photon emission computed tomography
- Influx constant
External links
- Medical encyclopedia article on Patlak plot
- Wikipedia's article - Patlak plot
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