Perphenazine

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Information about Perphenazine

Perphenazine is a phenothiazine and antipsychotic agent, now rarely used in clinical practice.

Liver safety of Perphenazine

Perphenazine can cause mild and transient serum enzyme elevations and is a rare cause of clinically apparent acute and chronic cholestatic liver injury.

Dosage and administration for Perphenazine

Perphenazine (per fen' a zeen) is a piperazine phenothiazine derivative which acts by postsynaptic inhibition of dopamine receptors. Perphenazine has other peripheral and central nervous system effects, producing both alpha adrenergic stimulation and blocking histamine- and serotonin-mediated effects.

FDA approval information for Perphenazine

Perphenazine is indicated for the therapy of acute and psychosis and is also used for management of nausea and vomiting. Perphenazine was approved for use in the United States in 1957 and was formerly a commonly prescribed antipsychotic, but in recent years, has been replaced in large part by the atypical antipsychotics, which have fewer extrapyramidal side effects.

Dosage and administration for Perphenazine

Perphenazine is available in generic forms as tablets of 2, 4, 8 and 16 mg and previously under the brand name of Trilafon. Oral solutions are also available. Typical doses used to treat schizopheria are 4 to 16 mg two to four times daily, attempting to reduce the dose as soon as possible to a minimum.

Side effects of Perphenazine

Common side effects include drowsiness, dizziness, headache, blurred vision, dry mouth, constipation, tremor, restlessness, muscle spasms and weight gain.

Antipsychotic agents

First Generation

Second Generation (Atypicals)


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