Pharmacometabolomics
Pharmacometabolomics
Pharmacometabolomics, also known as pharmacometabonomics, is a field of study that involves the application of metabolomics to better understand the pharmacokinetic and pharmacodynamic properties of drugs. Pronounced as "far-ma-ko-met-a-bo-lo-mics", the term is derived from the Greek words pharmakon (drug), metabole (change), and -omics (study of).
Etymology
The term "pharmacometabolomics" is a combination of three words: "pharmaco-" from the Greek pharmakon meaning drug, "metabolo-" from the Greek metabole meaning change, and "-omics" from the Greek -omikos meaning relating to. Thus, pharmacometabolomics can be understood as the study of the changes in metabolite levels in response to drug administration.
Overview
Pharmacometabolomics is a sub-discipline of metabolomics, which is the study of the unique chemical fingerprints that specific cellular processes leave behind. It aims to predict the response of individuals to a drug therapy by analyzing their metabolic profiles. This is achieved by using high-throughput techniques to analyze the metabolites in an individual's biological samples, such as blood or urine.
Pharmacometabolomics is closely related to pharmacogenomics, which studies how an individual's genetic makeup affects their response to drugs. Both fields aim to achieve personalized medicine, where drug therapy is tailored to an individual's unique genetic and metabolic profile.
Applications
Pharmacometabolomics has a wide range of applications in drug discovery and development, personalized medicine, and clinical pharmacology. It can be used to predict drug efficacy and safety, identify biomarkers for disease, and understand the mechanisms of drug action and drug-drug interactions.
Related Terms
- Metabolomics: The study of the unique chemical fingerprints that specific cellular processes leave behind.
- Pharmacogenomics: The study of how an individual's genetic makeup affects their response to drugs.
- Personalized medicine: A medical model that tailors treatment to the individual characteristics of each patient.
- Clinical pharmacology: The study of drugs and their clinical use.
External links
- Medical encyclopedia article on Pharmacometabolomics
- Wikipedia's article - Pharmacometabolomics
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