Pimozide

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Information about Pimozide

Pimozide is a conventional antipsychotic used largely in the therapy of Tourette syndrome.

Liver safety of Pimozide

Pimozide therapy has not been associated with serum aminotransferase elevations nor with cases of clinically apparent acute liver injury.

Mechanism of action of Pimozide

Pimozide (pim' oh zide) is a diphenylbutylpiperidine derivative that differs structurally from the phenothiazines and appears to act by blocking dopamine type 2 (D2) receptors. Pimozide has other central and peripheral effects including anticholinergeric and alpha adrenergic blockade. Pimozide is indicated for the therapy of severe motor and verbal tics in patients with Tourette syndrome. It has also been used in therapy of schizophrenia.

FDA approval information for Pimozide

Pimozide was approved for use in the United States in 1984. As therapy of schizophrenia, pimozide has been replaced in large part by the atypical antipsychotics, which have fewer extrapyramidal side effects. Pimozide continues to be used in patients with Tourette syndrome.

Dosage and administration for Pimozide

Pimozide is available as tablets of 1 and 2 mg in generic forms and under the brand name Orap. Typical doses are 1 to 2 mg daily in divided doses, increasing to a maximum of 10 mg daily. Pimozide can prolong the QT interval and, in rare instances, has caused sudden death for which reason the dose should be carefully chosen and drug levels monitored.

Side effects of Pimozide

Common side effects include drowsiness, dizziness, headache, blurred vision, dry mouth, and constipation.

Antipsychotic agents

First Generation

Second Generation (Atypicals)


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