Propofol infusion syndrome
Propofol Infusion Syndrome
Propofol Infusion Syndrome (Pronunciation: proh-POH-fohl in-FYOO-zhuhn SIN-drohm) is a rare but potentially fatal condition that can occur as a result of prolonged Propofol infusion. The syndrome is characterized by metabolic acidosis, rhabdomyolysis, hyperlipidemia, and cardiac failure.
Etymology
The term "Propofol Infusion Syndrome" is derived from the name of the drug Propofol, a short-acting, intravenously administered hypnotic/amnestic agent, and the word "infusion", which refers to the method of administering the drug. The word "syndrome" is used to describe a group of symptoms that consistently occur together.
Symptoms
The symptoms of Propofol Infusion Syndrome may include:
- Metabolic acidosis
- Rhabdomyolysis
- Hyperlipidemia
- Cardiac failure
Causes
Propofol Infusion Syndrome is typically caused by the prolonged infusion of high doses of Propofol. The exact mechanism of how Propofol causes this syndrome is not fully understood, but it is believed to be related to the drug's effects on the body's metabolism and the heart.
Treatment
Treatment for Propofol Infusion Syndrome primarily involves discontinuing the infusion of Propofol. Additional treatments may be necessary depending on the severity of the symptoms and may include supportive care, such as intravenous fluids and medications to manage symptoms.
Prevention
Prevention of Propofol Infusion Syndrome involves careful monitoring of patients receiving Propofol, particularly those receiving high doses or prolonged infusions. Regular monitoring of blood chemistry and cardiac function can help detect early signs of the syndrome.
See Also
External links
- Medical encyclopedia article on Propofol infusion syndrome
- Wikipedia's article - Propofol infusion syndrome
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