TATA box
TATA Box
The TATA box (/ˈtɑːtɑː/ or /ˈtætə/) is a DNA sequence that indicates where a genetic sequence can be read and decoded. It is a type of promoter sequence, which specifies to other molecules where transcription begins.
Etymology
The name "TATA box" comes from its conserved DNA sequence, which is most commonly TATAAA. The sequence is named for its discovery in the late 1970s by American biochemist David P. Groudine and his colleagues.
Function
The TATA box is crucial for the initiation of transcription in some genes. It is recognized and bound by a transcription factor known as TATA-binding protein (TBP), which helps in the recruitment of RNA polymerase II and other factors required for the initiation of transcription.
Related Terms
- Promoter (genetics): A region of DNA that initiates transcription of a particular gene.
- Transcription (biology): The first step of gene expression, where a particular segment of DNA is copied into RNA.
- Transcription factor: A protein that controls the rate of transcription of genetic information from DNA to messenger RNA.
- RNA polymerase II: An enzyme that catalyzes the transcription of DNA to synthesize precursors of mRNA and most snRNA and microRNA.
External links
- Medical encyclopedia article on TATA box
- Wikipedia's article - TATA box
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