Thioridazine

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Information about Thioridazine

Thioridazine is a phenothiazine and antipsychotic agent that is no longer in common use.

Liver safety of Thioridazine

Thioridazine has been linked to rare instances of clinically apparent acute cholestatic liver injury.

Mechanism of action of Thioridazine

Thioridazine is a piperazine phenothiazine derivative which acts by postsynaptic inhibition of dopamine receptors. Thioridazine has other peripheral and central nervous system effects, producing both alpha adrenergic stimulation and blocking histamine- and serotonin-mediated effects. Thioridazine is indicated for the therapy of acute and chronic psychosis.

FDA approval information for Thioridazine

Thioridazine was approved for use in the United States in 1978 and was formerly a commonly prescribed antipsychotic medication, but in recent years has been replaced in large part by the atypical antipsychotics, which have fewer extrapyramidal side effects. Use of thioridazine is also restricted because of its propensity to cause prolongation of the QTc interval and increased risk of sudden death.

Dosage and administration for Thioridazine

Thioridazine is available as tablets of 10, 25, 50 and 100 mg in generic forms and previously under the brand name Mellaril. The usual recommended dose in adults is 50 to 100 mg three times daily, increasing based upon effect and tolerance to a maximum of 800 mg daily.

Side effects of Thioridazine

Common side effects include drowsiness, dizziness, headache, blurred vision, dry mouth, constipation, tremor, restlessness, muscle spasms and weight gain.

Antipsychotic agents

First Generation

Second Generation (Atypicals)


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