Tocainide
Tocainide
Tocainide (pronounced: toh-KAY-nide) is a class 1b antiarrhythmic agent, which is primarily used in the treatment of ventricular arrhythmias. It is a derivative of lidocaine, but is orally active and has a longer duration of action.
Etymology
The term "Tocainide" is derived from its parent compound, Lidocaine, with the prefix "To-" added to differentiate it as a separate entity. The "-cainide" suffix is common in local anesthetics and antiarrhythmic agents, indicating its pharmacological class.
Pharmacology
Tocainide works by blocking the fast inward sodium channel, which is responsible for the rapid depolarization phase of the action potential in cardiac myocytes. This results in a decrease in the rate of phase 0 depolarization, which can help to stabilize the rhythm of the heart.
Related Terms
- Antiarrhythmic agent: A drug used to suppress abnormal rhythms of the heart, such as atrial fibrillation, atrial flutter, ventricular tachycardia, and ventricular fibrillation.
- Ventricular arrhythmias: A group of conditions in which the rhythm of the heartbeat is irregular or abnormal. This can occur in the ventricles of the heart.
- Lidocaine: A medication used to numb tissue in a specific area. It is also used to treat ventricular tachycardia and to perform nerve blocks.
Side Effects
Like all medications, Tocainide can cause side effects. Common side effects include dizziness, blurred vision, and nausea. More serious side effects can include heart problems such as a new or worsening arrhythmia.
See Also
External links
- Medical encyclopedia article on Tocainide
- Wikipedia's article - Tocainide
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