Transversion
Transversion
Transversion (pronounced: trans-ver-sion) is a type of point mutation in DNA that changes a purine nucleotide to a pyrimidine nucleotide or vice versa. It is contrasted with transition, which is a point mutation that changes a purine to another purine or a pyrimidine to another pyrimidine.
Etymology
The term "transversion" is derived from the Latin words "trans" meaning "across" and "versio" meaning "turning". It was first used in the context of genetics in the mid-20th century.
Description
In a transversion mutation, a purine base (adenine or guanine) is replaced with a pyrimidine base (cytosine or thymine), or a pyrimidine base is replaced with a purine base. This type of mutation can have a significant impact on the function of a gene, as it often results in a change in the amino acid sequence of the protein that the gene codes for.
Related Terms
- Point mutation: A type of mutation that affects a single nucleotide in the DNA sequence.
- Transition: A type of point mutation that changes a purine to another purine or a pyrimidine to another pyrimidine.
- Purine: One of the two types of nitrogenous bases in DNA and RNA, consisting of adenine and guanine.
- Pyrimidine: One of the two types of nitrogenous bases in DNA and RNA, consisting of cytosine, thymine (in DNA), and uracil (in RNA).
- Nucleotide: The basic building block of DNA and RNA, consisting of a sugar, a phosphate group, and a nitrogenous base.
External links
- Medical encyclopedia article on Transversion
- Wikipedia's article - Transversion
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