Trimetaphan camsilate
Trimetaphan camsilate
Trimetaphan camsilate (pronunciation: tri-met-a-phan cam-si-late) is a medication used in the management of hypertensive emergencies, specifically when blood pressure needs to be reduced immediately. It is also used to produce controlled hypotension during surgery to reduce bleeding.
Etymology
The term 'Trimetaphan camsilate' is derived from its chemical structure. 'Tri' refers to the three methoxy groups present in the compound, 'meta' refers to the position of these groups on the benzene ring, and 'phan' is derived from the Greek word 'phainein', meaning 'to show'. 'Camsilate' refers to the camphorsulfonic acid salt form of the drug.
Pharmacology
Trimetaphan camsilate is a ganglionic blocker, meaning it inhibits the transmission of nerve impulses in the autonomic ganglia, which are clusters of nerve cells. This results in a decrease in blood pressure. It is a non-depolarizing, competitive antagonist at the nicotinic acetylcholine receptor.
Related Terms
- Hypertension: A condition characterized by consistently high blood pressure.
- Hypotension: A condition characterized by abnormally low blood pressure.
- Ganglionic blocker: A type of drug that inhibits the transmission of nerve impulses in the autonomic ganglia.
- Nicotinic acetylcholine receptor: A type of protein that responds to the neurotransmitter acetylcholine.
See Also
External links
- Medical encyclopedia article on Trimetaphan camsilate
- Wikipedia's article - Trimetaphan camsilate
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