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Information about Vortioxetine

Vortioxetine is a serotonergic antidepressant used for major depression disorders. Vortioxetine has been associated with a low rate of minor serum aminotransferase elevations during treatment, but has not been linked to instances of clinically apparent acute liver injury.

Mechanism of action of Vortioxetine

Vortioxetine (vor" tye ox' e teen) is a unique serotonergic antidepressant that is believed to have a bimodal activity, inhibiting serotonin reuptake, but also acting as a mixed agonist and antagonist directly on serotonin (5-HT) receptors. Vortioxetine has been shown to be effective in alleviating symptoms of depression in patients with major depression disorder.

FDA approval information for Vortioxetine

Vortioxetine was approved for use in the United States in 2013 for use in treatment of major depression disorders. There is limited clinical experience with its use.

Brand name for Vortioxetine

Vortioxetine is available in tablets of 5, 10, 15 and 20 mg under the commercial name Brintellix.

Dosage and administration for Vortioxetine

The recommended dose is 10 mg once daily initially, with subsequent increase to as much as 20 mg daily based upon efficacy and tolerance. Doses of 5 mg can be used if 10 mg doses are not tolerated.

Side effects of Vortioxetine

Common side effects include nausea, constipation, dizziness, somnolence, headache and dry mouth. Less common and rare side effects include mood disorders, suicidal ideation, sexual dysfunction, serotonin syndrome, hypersensitivity reactions and precipitation of manic episodes.

The following are antidepressant subclasses and drugs

MAO Inhibitors Isocarboxazid, Phenelzine, Tranylcypromine

SNRIs Duloxetine, Levomilnacipran, Venlafaxine

SSRIs Citalopram, Escitalopram, Fluoxetine, Fluvoxamine, Paroxetine, Sertraline, Vilazodone, Vortioxetine

Tricyclics Amitriptyline, Amoxapine, Clomipramine, Desipramine, Doxepin, Imipramine, Nortriptyline, Protriptyline, Trimipramine

Miscellaneous Bupropion, Flibanserin, Mirtazapine, Nefazodone, Trazodone

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