Zaprinast
Zaprinast
Zaprinast (pronounced: zah-PRIN-ast) is a phosphodiesterase inhibitor used in scientific research. It was first synthesized in the 1970s and has been used in various studies related to vascular smooth muscle relaxation and cGMP-specific phosphodiesterase inhibition.
Etymology
The term "Zaprinast" is derived from the chemical name 2-Oxo-3-(3,4,5-trimethoxybenzoyl)-1-propenyl-1,2-dihydroquinoxaline-1,4-dione. The name was likely created by the original synthesizers of the compound, although the exact etymology is not known.
Usage
Zaprinast is primarily used in scientific research. It is a selective inhibitor of phosphodiesterase 5 (PDE5), which is an enzyme that breaks down cGMP in the body. By inhibiting this enzyme, Zaprinast increases the levels of cGMP in the body, which can lead to various effects such as relaxation of vascular smooth muscle.
Related Terms
- Phosphodiesterase inhibitor: A type of drug that inhibits phosphodiesterase enzymes, which are responsible for breaking down cGMP and cAMP in the body.
- Vascular smooth muscle: The type of muscle found in the walls of blood vessels. It contracts and relaxes to control blood flow and pressure.
- cGMP: Cyclic guanosine monophosphate, a molecule that acts as a signaling molecule in the body. It is broken down by phosphodiesterase enzymes.
- Phosphodiesterase 5 (PDE5): A specific type of phosphodiesterase enzyme that breaks down cGMP. Inhibitors of PDE5, like Zaprinast, are used to increase levels of cGMP in the body.
External links
- Medical encyclopedia article on Zaprinast
- Wikipedia's article - Zaprinast
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