Α-Eucaine

Α-Eucaine is a local anesthetic that was introduced as a substitute for cocaine in the early 20th century. It is a white, crystalline substance that is soluble in water and alcohol.

History

Α-Eucaine was first synthesized in 1900 by Alfred Einhorn, a German chemist who was searching for a less toxic and less addictive alternative to cocaine. Einhorn also synthesized procaine, another local anesthetic, which eventually replaced Α-Eucaine in clinical use.

Pharmacology

Like other local anesthetics, Α-Eucaine works by blocking sodium channels in nerve cells, preventing the transmission of nerve impulses and thus numbing the area. However, it is less potent than cocaine and has a slower onset of action.

Medical Use

Α-Eucaine was used in a variety of medical procedures, including dental surgery, minor surgery, and as a topical anesthetic for the skin and mucous membranes. However, it was found to be less effective than cocaine and was eventually replaced by other local anesthetics.

Side Effects

The side effects of Α-Eucaine are similar to those of other local anesthetics and include numbness, tingling, and temporary loss of sensation in the area where it is applied. In rare cases, it can cause allergic reactions.

See Also

• Local anesthetic
• Cocaine
• Procaine
• Alfred Einhorn

References

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Α-Eucaine

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  Α-Eucaine

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  Α-Eucaine synthesis