2-Ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine
2-Ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine
2-Ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) is a chemical compound that is primarily known as a metabolite of methadone. It is an important substance in the context of drug metabolism and forensic toxicology.
Chemical Structure
2-Ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine is a pyrrolidine derivative. The structure consists of a pyrrolidine ring with two methyl groups at the 1 and 5 positions, an ethylidene group at the 2 position, and two phenyl groups at the 3 position. This configuration contributes to its unique chemical properties and its role as a metabolite.
Metabolism of Methadone
Methadone is a synthetic opioid used for pain management and in the treatment of opioid use disorder. When methadone is metabolized in the body, it undergoes N-demethylation to form EDDP. This process is primarily facilitated by the cytochrome P450 enzyme system, particularly CYP3A4 and CYP2B6.
Role in Forensic Toxicology
EDDP is a significant marker in the detection of methadone use. In forensic toxicology, the presence of EDDP in biological samples such as urine or blood is used to confirm methadone ingestion. Unlike methadone, EDDP is not pharmacologically active, but its detection is crucial for compliance monitoring in methadone maintenance programs.
Analytical Detection
The detection of EDDP is typically performed using chromatography techniques such as gas chromatography-mass spectrometry (GC-MS) or liquid chromatography-tandem mass spectrometry (LC-MS/MS). These methods provide the sensitivity and specificity required to accurately identify EDDP in complex biological matrices.
Related Compounds
EDDP is one of several metabolites of methadone. Other related compounds include EDMP (2-ethyl-5-methyl-3,3-diphenylpyrrolidine), which is another minor metabolite. Understanding the metabolic pathways of methadone and its metabolites is important for both clinical and forensic applications.
See Also
Related Pages
2-Ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine
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