3-Methylhistidine
3-Methylhistidine
-2-amino-3-(3-methylimidazol-4-yl)propanoic_acid.svg)
3-Methylhistidine is a non-proteinogenic amino acid that is derived from the methylation of the amino acid histidine. It is primarily found in actin and myosin, which are proteins in muscle tissue.
Biochemistry
3-Methylhistidine is formed by the post-translational modification of histidine residues in muscle proteins. This modification is catalyzed by specific methyltransferase enzymes. Once incorporated into proteins, 3-methylhistidine is not reused in protein synthesis and is excreted in the urine.
Physiological Role
3-Methylhistidine is used as a biomarker for muscle protein breakdown. Since it is released during the degradation of actin and myosin, its presence in urine can be an indicator of muscle catabolism. This makes it useful in clinical settings to assess muscle wasting conditions.
Clinical Significance
The measurement of urinary 3-methylhistidine can be used to evaluate muscle protein turnover in various conditions such as cachexia, sarcopenia, and muscular dystrophy. It is also used in nutritional studies to assess the effects of dietary protein intake on muscle metabolism.
Metabolism
After being released from muscle proteins, 3-methylhistidine is not further metabolized in the body. It is filtered by the kidneys and excreted in the urine. This makes it a reliable marker for assessing muscle protein breakdown.
Related Compounds
Related Pages
3-Methylhistidine
Structure of 3-Methylhistidine
Transform your life with W8MD's budget GLP-1 injections from $125.
W8MD offers a medical weight loss program to lose weight in Philadelphia. Our physician-supervised medical weight loss provides:
- Most insurances accepted or discounted self-pay rates. We will obtain insurance prior authorizations if needed.
- Generic GLP1 weight loss injections from $125 for the starting dose.
- Also offer prescription weight loss medications including Phentermine, Qsymia, Diethylpropion, Contrave etc.
NYC weight loss doctor appointments
Start your NYC weight loss journey today at our NYC medical weight loss and Philadelphia medical weight loss clinics.
- Call 718-946-5500 to lose weight in NYC or for medical weight loss in Philadelphia 215-676-2334.
- Tags:NYC medical weight loss, Philadelphia lose weight Zepbound NYC, Budget GLP1 weight loss injections, Wegovy Philadelphia, Wegovy NYC, Philadelphia medical weight loss, Brookly weight loss and Wegovy NYC
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
