3-Methylhistidine
3-Methylhistidine
3-Methylhistidine (pronunciation: three-meth-ill-his-ti-deen) is a histidine derivative that is a normal component of skeletal muscle proteins. It is a biomarker for muscle protein breakdown.
Etymology
The term "3-Methylhistidine" is derived from the combination of the prefix "3-Methyl-", indicating the presence of a methyl group at the third position, and "histidine", a basic amino acid.
Function
3-Methylhistidine is a modified amino acid that is not reutilized for protein synthesis and is excreted in the urine. It is used as a biomarker to measure the rate of muscle protein breakdown in the body. High levels of 3-Methylhistidine in the urine can indicate increased muscle protein breakdown, which can occur in conditions such as muscular dystrophy, cachexia, and severe injury.
Related Terms
- Histidine: An essential amino acid that is used in the biosynthesis of proteins.
- Amino Acid: Organic compounds that combine to form proteins.
- Muscular Dystrophy: A group of diseases that cause progressive weakness and loss of muscle mass.
- Cachexia: A condition that causes extreme weight loss and muscle wasting.
- Skeletal Muscle: A type of muscle that is connected to the skeleton to form part of the mechanical system that moves the limbs and other parts of the body.
External links
- Medical encyclopedia article on 3-Methylhistidine
- Wikipedia's article - 3-Methylhistidine
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