4-Ethylphenyl sulfate

A sulfate ester of 4-ethylphenol

4-Ethylphenyl sulfate is a sulfate ester of 4-ethylphenol, a compound that is part of the phenol family. It is a metabolite that can be found in the human body and is often studied in the context of gut microbiota and its influence on human health.

Structure and Properties

4-Ethylphenyl sulfate has the chemical formula C₈H₁₀O₄S. It consists of a phenyl ring with an ethyl group attached to the fourth carbon and a sulfate group attached to the phenolic oxygen. The presence of the sulfate group makes it more water-soluble compared to its parent compound, 4-ethylphenol.

Chemical structure of 4-Ethylphenyl sulfate

Biological Significance

4-Ethylphenyl sulfate is a significant metabolite in the human body, particularly in the context of gut microbiota metabolism. It is produced by the sulfation of 4-ethylphenol, a process that occurs in the liver. This compound is often used as a biomarker for certain metabolic activities within the gut.

Role in Health and Disease

The levels of 4-ethylphenyl sulfate in the body can be indicative of various health conditions. It has been studied in relation to autism spectrum disorder, where altered levels have been observed. Additionally, it is of interest in the study of chronic kidney disease, as its accumulation can occur when renal function is impaired.

Metabolism

4-Ethylphenyl sulfate is primarily formed in the liver through the action of sulfotransferase enzymes, which transfer a sulfate group to 4-ethylphenol. This process is part of the body's detoxification pathways, helping to increase the solubility of phenolic compounds for excretion.

Related Compounds

• 4-Ethylphenol
• Phenol
• Sulfate esters

Related Pages

• Gut microbiota
• Metabolite
• Sulfation
• Autism spectrum disorder

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  Structure of 4-Ethylphenyl sulfate