4-Nitroquinoline 1-oxide
4-Nitroquinoline 1-oxide
4-Nitroquinoline 1-oxide (pronounced as four-nitro-kwin-o-leen one-oxide) is a potent mutagen and carcinogen.
Etymology
The term "4-Nitroquinoline 1-oxide" is derived from its chemical structure. The "4-Nitro" part refers to the nitro group (-NO2) attached to the 4th position of the quinoline ring. The "1-oxide" part refers to the oxygen atom attached to the 1st position of the quinoline ring.
Definition
4-Nitroquinoline 1-oxide is a yellow crystalline substance that is used primarily in biochemical research involving induction of mutations. It is known to cause mutations by inserting itself into the DNA and causing errors during DNA replication.
Related Terms
- Mutagen: An agent, such as radiation or a chemical substance, that causes genetic mutation.
- Carcinogen: A substance capable of causing cancer in living tissue.
- DNA replication: The process by which a double-stranded DNA molecule is copied to produce two identical DNA molecules.
Usage in Research
4-Nitroquinoline 1-oxide is used in research to study the mechanisms of DNA damage and repair, and the processes leading to carcinogenesis. It is also used as a positive control in experiments investigating the mutagenic potential of other substances.
Health Effects
Exposure to 4-Nitroquinoline 1-oxide can lead to various health effects, including skin and eye irritation, respiratory problems, and potential long-term effects such as cancer. It is classified as a Group 2A carcinogen by the International Agency for Research on Cancer (IARC), meaning it is probably carcinogenic to humans.
Safety and Handling
Due to its mutagenic and carcinogenic properties, 4-Nitroquinoline 1-oxide should be handled with extreme care. It is recommended to use personal protective equipment, including gloves and eye protection, when handling this substance.
External links
- Medical encyclopedia article on 4-Nitroquinoline 1-oxide
- Wikipedia's article - 4-Nitroquinoline 1-oxide
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