5-Methyluridine triphosphate
5-Methyluridine Triphosphate
5-Methyluridine Triphosphate (m5UTP) is a nucleotide analog of uridine triphosphate (UTP) where the uracil base is methylated at the 5th carbon position. This modification is significant in various biological processes, particularly in the context of RNA synthesis and epigenetics.
Structure
5-Methyluridine Triphosphate consists of the nucleoside 5-methyluridine, which is linked to a triphosphate group. The methyl group at the 5th position of the uracil ring distinguishes it from the standard uridine triphosphate. This methylation can affect the molecule's interaction with enzymes and nucleic acids.
Biological Role
In biological systems, 5-Methyluridine Triphosphate can be incorporated into RNA during transcription, potentially affecting the stability and function of the RNA molecule. Methylation of uridine residues is a common post-transcriptional modification that can influence gene expression and RNA processing.
Synthesis
5-Methyluridine Triphosphate can be synthesized in vitro through enzymatic or chemical methods. The synthesis involves the methylation of uridine followed by phosphorylation to add the triphosphate group. This process is crucial for studying the effects of methylation on RNA function and for developing nucleotide analogs for therapeutic purposes.
Applications
5-Methyluridine Triphosphate is used in research to study the effects of RNA methylation on cellular processes. It is also utilized in the development of RNA-based therapeutics and as a tool in molecular biology to investigate the role of modified nucleotides in RNA structure and function.
Related Pages
Gallery
Structure of 5-Methyluridine Triphosphate
3D space-filling model of 5-Methyluridine Triphosphate anion
5-Methyluridine triphosphate
5-Methyluridine triphosphate protonated structure
5-Methyluridine triphosphate anion 3D spacefill model
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