Acetylmethadol

A synthetic opioid analgesic

Acetylmethadol
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Acetylmethadol is a synthetic opioid analgesic that is chemically related to methadone. It is used primarily in the treatment of opioid dependence and is known for its long-acting properties. Acetylmethadol is a racemic mixture, meaning it contains two enantiomers, which are mirror images of each other.

Pharmacology

Acetylmethadol acts on the mu-opioid receptor in the central nervous system, producing effects similar to those of other opioids, such as analgesia, euphoria, and respiratory depression. Its long duration of action makes it suitable for use in opioid substitution therapy.

Synthesis and Structure

The chemical structure of acetylmethadol is similar to that of methadone, with the addition of an acetyl group. This modification affects its pharmacokinetics, allowing for a longer duration of action. The structural formula of acetylmethadol is depicted in the image on the right.

Structural formula of acetylmethadol

Clinical Use

Acetylmethadol is used in the management of opioid dependence, providing a longer-acting alternative to methadone. It is administered orally and is typically used in a controlled clinical setting. The drug helps to reduce withdrawal symptoms and cravings in individuals undergoing treatment for opioid addiction.

Side Effects

Common side effects of acetylmethadol include nausea, vomiting, constipation, and drowsiness. As with other opioids, there is a risk of addiction and overdose, particularly if the drug is not used as prescribed.

Regulation

Due to its potential for abuse and addiction, acetylmethadol is classified as a controlled substance in many countries. Its use is typically restricted to specific medical settings and requires careful monitoring by healthcare professionals.

Related pages

• Methadone
• Opioid dependence
• Opioid receptor