Acute eosinophilic leukemia

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Acute Eosinophilic Leukemia (AEL) is a rare subtype of Acute Myeloid Leukemia (AML) characterized by the rapid proliferation of abnormal eosinophils in the bone marrow and blood. The pronunciation is /əˈkjuːt iːəʊsɪˈnɪfɪlɪk luːˈkiːmiːə/. The term is derived from the Greek words "akutus" meaning sharp or severe, "eosin" meaning dawn-colored (referring to the pink color of eosinophils when stained), "philos" meaning loving, and "leukemia" meaning white blood.

Symptoms

The symptoms of Acute Eosinophilic Leukemia can vary but often include fever, fatigue, weight loss, and night sweats. Other symptoms may include skin rashes, difficulty breathing, and organ damage due to the infiltration of eosinophils.

Diagnosis

Diagnosis of Acute Eosinophilic Leukemia is often challenging due to its rarity and the nonspecific nature of the symptoms. It typically involves a complete blood count (CBC), bone marrow biopsy, and cytogenetic analysis.

Treatment

Treatment options for Acute Eosinophilic Leukemia typically involve chemotherapy, such as Cytarabine and Idarubicin, and targeted therapies. In some cases, a stem cell transplant may be considered.

Prognosis

The prognosis of Acute Eosinophilic Leukemia is generally poor, with a median survival of less than two years. However, outcomes can vary significantly depending on factors such as patient age, overall health, and response to treatment.

See Also

External links

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