Aldosterone
From WikiMD's WELLNESSPEDIA
Aldosterone[edit]
Aldosterone is a mineralocorticoid hormone produced by the adrenal cortex, in the adrenal gland. It plays a pivotal role in regulating sodium and potassium balance, and thus, has significant implications on blood pressure and fluid balance in the body.
Function[edit]
Aldosterone acts on the distal tubules and collecting ducts of the nephron (functional unit of the kidney) to:
- Increase Sodium Reabsorption: This leads to water reabsorption, thereby increasing the blood volume and blood pressure.
- Increase Potassium Excretion: To maintain electrolyte balance.
The secretion of Aldosterone is primarily regulated by the Renin-Angiotensin-Aldosterone System (RAAS).
Clinical Significance[edit]
- Hyperaldosteronism: Excess production of Aldosterone can lead to hypertension and hypokalemia.
- Addison's disease: A deficiency in Aldosterone production can result in low blood pressure and hyperkalemia.
- Aldosterone antagonists: Medications such as spironolactone and eplerenone block the effects of Aldosterone and are used to treat conditions like heart failure and hypertension.
See Also[edit]
References[edit]
- "Aldosterone and its physiological roles" - Journal of Endocrinology.
- "Clinical aspects of hyperaldosteronism" - Endocrine Reviews.
