Amelanotic melanoma

Editor-In-Chief: Prab R Tumpati, MD
Obesity, Sleep & Internal medicine
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Amelanotic melanoma
Amelanotic melanoma
Synonyms	N/A
Pronounce	N/A
Specialty	N/A
Symptoms	Skin lesions, ulceration, bleeding, itching
Complications	Metastasis to lymph nodes, lungs, liver, brain
Onset	Typically in adulthood
Duration	Chronic
Types	N/A
Causes	Genetic mutations, UV radiation
Risks	Fair skin, family history of melanoma, immunosuppression
Diagnosis	Biopsy, dermoscopy, imaging studies
Differential diagnosis	Basal cell carcinoma, squamous cell carcinoma, benign nevus
Prevention	N/A
Treatment	Surgical excision, immunotherapy, targeted therapy, radiation therapy
Medication	N/A
Prognosis	Variable, depends on stage and metastasis
Frequency	Rare compared to pigmented melanoma
Deaths	N/A

Amelanotic Melanoma

Amelanotic melanoma is a type of melanoma that lacks the dark pigmentation typically associated with melanocytic tumors. Unlike conventional melanomas, which are characterized by the presence of melanin, amelanotic melanomas appear as pink, red, or skin-colored lesions. This lack of pigmentation can make them more challenging to diagnose.

Pathophysiology

Amelanotic melanoma arises from the malignant transformation of melanocytes, the cells responsible for producing melanin. In amelanotic variants, these cells lose their ability to produce pigment, resulting in the absence of the characteristic dark coloration. The exact mechanisms leading to the loss of pigmentation are not fully understood, but genetic mutations and alterations in melanin synthesis pathways are thought to play a role.

Clinical Presentation

Amelanotic melanomas can present as irregularly shaped lesions that may be pink, red, or flesh-colored. They often lack the typical features of pigmented melanomas, such as asymmetry, border irregularity, color variation, and diameter greater than 6 mm. This atypical presentation can lead to delays in diagnosis, as the lesions may be mistaken for benign skin conditions.

Diagnosis

The diagnosis of amelanotic melanoma is challenging due to its atypical appearance. Dermatologists often rely on dermoscopy to identify subtle features that may suggest malignancy. A biopsy is essential for definitive diagnosis, allowing for histopathological examination. Immunohistochemical staining can help identify melanocytic origin by detecting markers such as S-100, HMB-45, and Melan-A.

Treatment

The treatment of amelanotic melanoma is similar to that of other types of melanoma. Surgical excision with clear margins is the primary treatment modality. Depending on the stage and location of the tumor, additional treatments such as immunotherapy, targeted therapy, or radiation therapy may be indicated. Early detection and treatment are crucial for improving outcomes.

Prognosis

The prognosis of amelanotic melanoma depends on several factors, including the stage at diagnosis, tumor thickness, and presence of metastasis. Due to its atypical presentation, amelanotic melanoma is often diagnosed at a more advanced stage, which can negatively impact prognosis. Regular skin examinations and awareness of changes in skin lesions are important for early detection.

Related Pages

• Melanoma
• Skin cancer
• Dermatology
• Oncology