Anisomycin
Anisomycin
Anisomycin (pronounced: an-iso-my-sin), also known as flagecidin is a pyrrolidine antibiotic that inhibits protein synthesis. It is produced by the bacterium Streptomyces griseolus.
Etymology
The term "Anisomycin" is derived from the Greek words "anisos" meaning unequal and "mykes" meaning fungus. This refers to the irregular shape of the Streptomyces griseolus bacterium that produces it.
Usage
Anisomycin is primarily used in scientific research as an inhibitor of protein synthesis in eukaryotic cells. It is known to activate stress-activated protein kinases, induce DNA damage, and inhibit peptide bond formation by the ribosome.
Related Terms
- Protein Synthesis: The process by which individual cells construct proteins.
- Eukaryotic Cells: Cells that contain a nucleus and other organelles enclosed within membranes.
- Stress-Activated Protein Kinases: A family of protein kinases involved in cellular stress response.
- DNA Damage: Changes to the chemical structure of DNA.
- Peptide Bond: A chemical bond formed between two molecules when the carboxyl group of one molecule reacts with the amino group of the other molecule.
- Ribosome: A complex molecular machine, found within all living cells, that serves as the site of biological protein synthesis.
External links
- Medical encyclopedia article on Anisomycin
- Wikipedia's article - Anisomycin
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