BRD2

Protein BRD2 PDB 1x0j

BRD2

BRD2 is a gene that encodes the bromodomain-containing protein 2. This protein is involved in chromatin remodeling and transcriptional regulation. The BRD2 gene is located on chromosome 6 in humans.

Function

The BRD2 protein contains bromodomains, which are protein modules that recognize acetylated lysine residues on histone proteins. By binding to acetylated histones, BRD2 can regulate gene expression by influencing chromatin structure.

Role in Disease

Mutations in the BRD2 gene have been associated with certain diseases, including cancer and neurological disorders. Dysregulation of BRD2 expression can lead to abnormal cell growth and differentiation, contributing to the development of cancer. In neurological disorders, alterations in BRD2 function may affect neuronal development and function.

Research

Research on BRD2 has focused on understanding its role in gene regulation and disease pathogenesis. Studies have investigated the molecular mechanisms by which BRD2 influences chromatin structure and gene expression. Additionally, researchers are exploring the potential therapeutic implications of targeting BRD2 in disease treatment.

See also

• Bromodomain
• Chromatin remodeling
• Gene regulation

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