Bucinnazine
Bucinnazine' (INN: AP-237, chemical name: 1-butyryl-4-cinnamylpiperazine) is an opioid analgesic drug that was widely used in China to treat pain in cancer patients as of 1986. It is recognized for its significant analgesic properties, being one of the most potent compounds among a series of piperazine-amides first synthesized and reported in Japan in the 1970s.
Chemistry
Bucinnazine belongs to a class of piperazine-amides, characterized by its chemical structure which includes a butyryl group and a cinnamyl group attached to a piperazine ring. This structural specificity contributes to its high potency as an analgesic.
Pharmacology
Bucinnazine has been reported to have analgesic potency comparable to that of morphine, but with a relatively higher therapeutic index. This suggests that bucinnazine can provide effective pain relief while having a lower risk of side effects compared to other opioids.
Clinical Use
Primarily, bucinnazine has been utilized in the management of pain associated with cancer. Its effectiveness in pain management made it a valuable option in palliative care settings, especially within China during the late 20th century.
History
The synthesis and analgesic properties of bucinnazine and related piperazine-amides were first reported in the 1970s by researchers in Japan. Its adoption in clinical practice, particularly in China by 1986, marks a significant period in the development of pain management therapies.
Related Terms
- Opioid: A class of drugs that includes both natural and synthetic substances, used primarily for pain relief.
- Analgesic: A type of medication used to relieve pain.
- Piperazine: A chemical compound that serves as a backbone for a variety of pharmaceutical agents, including bucinnazine.
- Morphine: A potent opioid analgesic drug used for severe pain management.
External links
- Medical encyclopedia article on Bucinnazine
- Wikipedia's article - Bucinnazine
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