CCR3

CCR3 or C-C chemokine receptor type 3 is a protein that in humans is encoded by the CCR3 gene. CCR3 is a member of the G protein-coupled receptor family, and is a receptor for C-C type chemokines. This receptor may play a role in both inflammatory and neurodegenerative diseases.

Function

CCR3 is a G protein-coupled receptor that is preferentially expressed on eosinophils and basophils. It is involved in eosinophil activation and survival, as well as in the trafficking of these cells to inflammatory sites. CCR3 is also expressed on Th2 cells, where it may contribute to the recruitment of these cells to sites of allergic inflammation.

Clinical significance

CCR3 has been implicated in a number of diseases, including asthma, allergic rhinitis, and atopic dermatitis. In addition, it has been suggested that CCR3 may play a role in the pathogenesis of Alzheimer's disease.

See also

• Chemokine receptor
• G protein-coupled receptor
• Eosinophil
• Basophil
• Th2 cells

External links

• CCR3 at the US National Library of Medicine Medical Subject Headings (MeSH)