CD79A

CD79A is a protein that in humans is encoded by the CD79A gene. It is also known as Ig-alpha (Immunoglobulin-alpha) and is a component of the B-cell antigen receptor (BCR). The CD79A molecule plays a crucial role in B cell development and antigen receptor signaling.

Function

CD79A and CD79B (Ig-beta) proteins are integral components of the B cell receptor (BCR) complex, which is involved in the development and maturation of B cells. The BCR complex plays a critical role in B cell activation and function. The CD79A molecule is necessary for initiating antigen receptor signals, which influence B cell development and immune response.

Clinical significance

Mutations in the CD79A gene have been associated with agammaglobulinemia-3, a type of primary immunodeficiency characterized by the failure of B cells to produce immunoglobulins. This condition leads to recurrent bacterial infections in affected individuals.

Interactions

CD79A has been shown to interact with CD79B, LYN, and Syk.

See also

• Cluster of differentiation
• B cell receptor
• Primary immunodeficiency

External links

• CD79A at the US National Library of Medicine Medical Subject Headings (MeSH)

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