Calcimimetic
Calcimimetic
Calcimimetic (pronounced kal-si-MIM-et-ik) is a type of drug used primarily in the treatment of hyperparathyroidism.
Etymology
The term "calcimimetic" is derived from the Latin calcis meaning "lime" or "limestone", and the Greek mimētikos meaning "imitative". This refers to the drug's ability to mimic the action of calcium in the body.
Definition
Calcimimetics are a class of drugs that mimic the action of calcium on tissues, by allosterically activating the calcium-sensing receptor (CaSR) that is expressed in various human organ tissues.
Usage
Calcimimetics are used to treat secondary hyperparathyroidism in patients with chronic kidney disease on dialysis and parathyroid carcinoma. They can also be used to manage hypercalcemia in patients with parathyroid carcinoma and primary and secondary hyperparathyroidism.
Related Terms
- Hyperparathyroidism: A condition characterized by an overactive parathyroid gland, which results in higher levels of calcium in the blood.
- Calcium-sensing receptor (CaSR): A class C G-protein coupled receptor which senses extracellular levels of calcium ion.
- Parathyroid carcinoma: A rare cancer resulting in the overproduction of parathyroid hormone.
- Allosteric activation: The regulation of an enzyme or protein that occurs when the binding of a molecule to a protein affects the binding of another molecule.
See Also
External links
- Medical encyclopedia article on Calcimimetic
- Wikipedia's article - Calcimimetic
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