Candoxatril

An overview of the drug Candoxatril

Candoxatril
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Candoxatril is a pharmaceutical compound that acts as a prodrug for candoxatrilat, an inhibitor of the enzyme neutral endopeptidase (NEP). It has been studied for its potential therapeutic effects in conditions such as hypertension and heart failure.

Mechanism of Action

Candoxatril is converted in the body to its active form, candoxatrilat, which inhibits the activity of neutral endopeptidase. NEP is an enzyme responsible for the breakdown of several vasoactive peptides, including atrial natriuretic peptide (ANP), bradykinin, and endothelin. By inhibiting NEP, candoxatrilat increases the levels of these peptides, leading to vasodilation and increased natriuresis, which can help lower blood pressure and reduce cardiac workload.

Pharmacokinetics

Candoxatril is administered orally and is rapidly absorbed from the gastrointestinal tract. It undergoes first-pass metabolism to form candoxatrilat, which is the active metabolite responsible for its pharmacological effects. The bioavailability of candoxatrilat is influenced by factors such as food intake and liver function.

Clinical Applications

Candoxatril has been investigated primarily for its potential use in treating hypertension and heart failure. By inhibiting NEP, it can enhance the effects of endogenous natriuretic peptides, leading to improved cardiovascular outcomes. However, its clinical use has been limited due to the development of more effective and safer alternatives.

Side Effects

The use of candoxatril can be associated with several side effects, including hypotension, dizziness, and gastrointestinal disturbances. These side effects are generally related to its vasodilatory effects and the increase in circulating vasoactive peptides.

Research and Development

Research into candoxatril and other NEP inhibitors has provided valuable insights into the role of natriuretic peptides in cardiovascular health. Although candoxatril itself is not widely used, the concept of NEP inhibition has led to the development of other therapeutic agents, such as sacubitril, which is used in combination with valsartan in the treatment of heart failure.

Related pages

• Neutral endopeptidase
• Atrial natriuretic peptide
• Hypertension
• Heart failure