Caroxazone

Caroxazone

Caroxazone is a monoamine oxidase inhibitor (MAOI) and anxiolytic that was introduced in the 1960s by the pharmaceutical company Roche. It is used primarily in the treatment of depression and anxiety disorders.

Pharmacology

Caroxazone acts by inhibiting the enzyme monoamine oxidase, which is responsible for the breakdown of monoamine neurotransmitters such as serotonin, norepinephrine, and dopamine in the brain. By inhibiting this enzyme, Caroxazone increases the levels of these neurotransmitters in the brain, which can help to alleviate symptoms of depression and anxiety.

Clinical Use

Caroxazone is used primarily in the treatment of depression and anxiety disorders. It has also been used to a lesser extent in the treatment of Parkinson's disease and other movement disorders, due to its ability to increase levels of dopamine in the brain.

Side Effects

Like other MAOIs, Caroxazone can cause a number of side effects, including hypertension, insomnia, and nausea. It can also cause a potentially serious condition known as serotonin syndrome if taken in combination with other drugs that increase serotonin levels.

Contraindications

Caroxazone is contraindicated in individuals with a history of hypertensive crisis or pheochromocytoma, due to the risk of severe hypertension. It is also contraindicated in individuals taking other MAOIs or certain other medications, due to the risk of serotonin syndrome.

See Also

• Monoamine oxidase inhibitor
• Anxiolytic
• Depression
• Anxiety disorders

This article is a stub related to pharmacology. You can help WikiMD by expanding it!

This article is a stub related to pharmacology. You can help WikiMD by expanding it!