Cetilistat
Cetilistat is a drug designed to treat obesity. It acts in the same way as the older drug orlistat (Xenical) by inhibiting pancreatic lipase, an enzyme that breaks down triglycerides in the intestine. Without this enzyme, triglycerides from the diet are prevented from being hydrolyzed into absorbable free fatty acids and are excreted undigested.
History
Cetilistat was developed by Alizyme, a biopharmaceutical company based in the United Kingdom. The drug was approved for the treatment of obesity in Japan by the Pharmaceuticals and Medical Devices Agency (PMDA) in September 2013. It is marketed in Japan by Takeda under the brand name Cetislim.
Mechanism of Action
Cetilistat works by inhibiting the action of pancreatic lipase, a lipolytic enzyme produced by the pancreas. This enzyme is responsible for the breakdown of triglycerides in the small intestine. When the activity of this enzyme is blocked, triglycerides from the diet are not hydrolyzed into absorbable free fatty acids, but are excreted in the feces. This reduces caloric intake and helps to decrease body weight.
Clinical Trials
In clinical trials, cetilistat was found to have similar efficacy to orlistat, but with fewer gastrointestinal side effects. In a phase 2 trial involving 612 obese patients, cetilistat significantly reduced body weight and was well-tolerated.
Side Effects
The most common side effects of cetilistat are gastrointestinal, including fatty or oily stool, increased defecation, and fecal incontinence. These side effects are generally mild and transient.
See Also
This medication related article is a stub. You can help WikiMD by expanding it.
Transform your life with W8MD's budget GLP-1 injections from $125.
W8MD offers a medical weight loss program to lose weight in Philadelphia. Our physician-supervised medical weight loss provides:
- Most insurances accepted or discounted self-pay rates. We will obtain insurance prior authorizations if needed.
- Generic GLP1 weight loss injections from $125 for the starting dose.
- Also offer prescription weight loss medications including Phentermine, Qsymia, Diethylpropion, Contrave etc.
NYC weight loss doctor appointments
Start your NYC weight loss journey today at our NYC medical weight loss and Philadelphia medical weight loss clinics.
- Call 718-946-5500 to lose weight in NYC or for medical weight loss in Philadelphia 215-676-2334.
- Tags:NYC medical weight loss, Philadelphia lose weight Zepbound NYC, Budget GLP1 weight loss injections, Wegovy Philadelphia, Wegovy NYC, Philadelphia medical weight loss, Brookly weight loss and Wegovy NYC
|
WikiMD's Wellness Encyclopedia |
| Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD
