Chromosome 15
Chromosome 15
Chromosome 15 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 15 spans about 102 million base pairs (the building material of DNA) and represents between 3 and 3.5 percent of the total DNA in cells.
Pronunciation
- Chromosome: /ˈkroʊməˌsoʊm/
- 15: /ˌfɪfˈtiːn/
Etymology
The term "chromosome" comes from the Greek words "chroma" or color and "soma" or body. The number 15 is derived from the Old English "fiftyne," which is a combination of "fif," the Old English word for "five," and "tene," a suffix meaning "-teen."
Related Terms
Genetic Disorders Linked to Chromosome 15
Several genetic disorders are linked to Chromosome 15. These include:
- Prader-Willi syndrome: This is caused by the loss of function of genes in a specific part of chromosome 15 (15q11-q13). This loss is usually caused by deletion of a segment of the paternal chromosome 15.
- Angelman syndrome: This is also caused by the loss of function of a different set of genes in the same part of chromosome 15 (15q11-q13). However, this loss is usually caused by deletion of a segment of the maternal chromosome 15.
- Marfan syndrome: This is caused by mutations in the FBN1 gene located on chromosome 15 (15q21.1).
See Also
External links
- Medical encyclopedia article on Chromosome 15
- Wikipedia's article - Chromosome 15
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