Clodronate disodium
Clodronate Disodium
Clodronate Disodium (pronunciation: klo-DROH-nate dye-SOH-dee-uhm) is a type of bisphosphonate medication used primarily in the treatment of osteoporosis and Paget's disease.
Etymology
The term "Clodronate" is derived from the chemical name chloromethylene diphosphonic acid. "Disodium" refers to the presence of two sodium ions in the compound.
Usage
Clodronate Disodium is used to slow down bone loss, increase bone density, and reduce the risk of spine and non-spine fractures. It is also used to treat high levels of calcium in the blood that may occur with some types of cancer.
Mechanism of Action
Clodronate Disodium works by binding to hydroxyapatite in bone tissue, inhibiting the activity of osteoclasts, the cells that break down bone, thereby preventing bone loss and maintaining bone strength.
Side Effects
Common side effects of Clodronate Disodium include nausea, vomiting, and diarrhea. In rare cases, it can cause serious side effects like osteonecrosis of the jaw and atypical femoral fractures.
Related Terms
- Bisphosphonates
- Osteoporosis
- Paget's disease
- Hydroxyapatite
- Osteoclasts
- Osteonecrosis
- Atypical femoral fractures
External links
- Medical encyclopedia article on Clodronate disodium
- Wikipedia's article - Clodronate disodium
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