D1-like receptor

D1-like receptor is a type of G protein-coupled receptor that is associated with the dopamine neurotransmitter. It is a subtype of dopamine receptor and is primarily found in the central nervous system. The D1-like receptor family includes two subtypes: D1 and D5.

Function

D1-like receptors are involved in a variety of neurological processes, including motor control, cognition, reward, and learning. They are activated by the neurotransmitter dopamine, which binds to the receptor and triggers a series of intracellular events. This leads to changes in the activity of the neuron, which can influence behavior and cognition.

Structure

Like all G protein-coupled receptors, D1-like receptors have seven transmembrane domains. They are coupled to the G protein Gs, which activates the enzyme adenylyl cyclase when the receptor is activated. This leads to an increase in the concentration of the second messenger cyclic AMP in the cell.

Clinical significance

Dysfunction of D1-like receptors has been implicated in a number of neurological and psychiatric disorders, including schizophrenia, Parkinson's disease, and drug addiction. Drugs that target these receptors, such as antipsychotics and antidepressants, are used in the treatment of these conditions.

See also

• Dopamine receptor
• G protein-coupled receptor
• Neurotransmitter

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