DDX11
DDX11
DDX11 (pronounced: D-D-X-eleven), also known as ChlR1 or Chl1, is a gene that encodes a DNA helicase in humans. This gene is associated with Warsaw breakage syndrome, a rare congenital disorder.
Etymology
The term DDX11 is an abbreviation for "DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11". The DEAD/H box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp/His (DEAD/H), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly.
Function
The DDX11 gene is a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. The DDX11 protein is a DNA helicase that is important for DNA replication and sister chromatid cohesion.
Related Terms
- DEAD box protein: A family of proteins characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD). They are putative RNA helicases.
- Warsaw breakage syndrome: A rare congenital disorder associated with the DDX11 gene.
- DNA replication: The process of producing two identical replicas from one original DNA molecule.
- Sister chromatid cohesion: The process by which sister chromatids are paired and held together from the time of their formation in S phase until their separation in anaphase.
See Also
External links
- Medical encyclopedia article on DDX11
- Wikipedia's article - DDX11
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