DdRNAi
DdRNAi
DdRNAi (pronounced as Dee-dee-R-N-A-i), also known as Double-stranded RNA interference, is a biological process where double-stranded RNA inhibits the expression of a gene with a similar sequence. This process is a type of RNA interference (RNAi) and is a crucial mechanism in many organisms, including humans, for regulating gene expression and defending against viruses.
Etymology
The term "DdRNAi" is an abbreviation for "Double-stranded RNA interference". The term "RNA interference" was first used in 1998 by Andrew Fire and Craig Mello, who won the Nobel Prize in Physiology or Medicine in 2006 for their discovery of the process.
Process
In DdRNAi, double-stranded RNA (dsRNA) is processed into small interfering RNAs (siRNAs) by an enzyme called Dicer. These siRNAs then guide the RNA-induced silencing complex (RISC) to degrade messenger RNA (mRNA) with a complementary sequence, thereby preventing the mRNA from being translated into protein.
Applications
DdRNAi has been used in research to study gene function by silencing specific genes. It also has potential applications in medicine, such as in the treatment of viral infections and cancer.
Related Terms
- RNA interference (RNAi)
- Small interfering RNA (siRNA)
- Dicer
- RNA-induced silencing complex (RISC)
- Messenger RNA (mRNA)
External links
- Medical encyclopedia article on DdRNAi
- Wikipedia's article - DdRNAi
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