Delucemine
Delucemine is a psychedelic and dissociative drug of the arylcyclohexylamine class. It is closely related to ketamine and phencyclidine (PCP) and has similar pharmacological effects.
History
Delucemine was first synthesized in the late 20th century, but its psychoactive properties were not discovered until the early 21st century. It is one of the few arylcyclohexylamines to have been sold commercially, albeit briefly and in very limited quantities, as a designer drug.
Pharmacology
Like other arylcyclohexylamines, delucemine acts primarily as an NMDA receptor antagonist. This means it blocks the action of the neurotransmitter glutamate at the NMDA receptor, which is responsible for the sensation of pain and the formation of memories. This can result in a state of dissociation, or disconnection from one's physical body and the external world.
In addition to its NMDA antagonist properties, delucemine also has some activity at the serotonin and dopamine receptors, which may contribute to its psychedelic effects.
Effects
The effects of delucemine are similar to those of other dissociative drugs like ketamine and PCP. These can include feelings of detachment from one's body, alterations in sensory perception, and changes in the perception of time and space. At higher doses, delucemine can induce a state of complete dissociation known as a "K-hole".
Legal status
The legal status of delucemine varies by country. In some jurisdictions, it is classified as a controlled substance and its sale, possession, and use are subject to legal restrictions.
See also
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Contributors: Prab R. Tumpati, MD