Diet-induced obesity model

Diet-induced obesity model is a widely used experimental model in biomedical research that mimics the human condition of obesity and its associated metabolic disorders. This model is created by feeding animals, usually rodents, a high-fat diet (HFD) that is rich in saturated fats and sugars.

Overview

The Diet-induced obesity model is a research tool used to study the physiological and molecular mechanisms underlying obesity and its related metabolic disorders such as type 2 diabetes, cardiovascular disease, and non-alcoholic fatty liver disease. The model is created by feeding animals, usually rodents, a high-fat diet (HFD) that is rich in saturated fats and sugars. The HFD induces obesity and metabolic disorders in the animals, which can then be studied to understand the pathogenesis of these conditions in humans.

Mechanism

The mechanism of diet-induced obesity involves the overconsumption of energy-dense foods, leading to an energy imbalance and excess fat accumulation. The HFD induces insulin resistance, a key feature of metabolic syndrome, by increasing the levels of free fatty acids and inflammatory cytokines in the body. These factors interfere with insulin signaling, leading to impaired glucose uptake and hyperglycemia.

Applications

The diet-induced obesity model is used in various areas of biomedical research. It is used to study the pathogenesis of obesity and its related metabolic disorders, to test the efficacy of anti-obesity drugs, and to investigate the effects of dietary interventions on obesity and metabolic health.

Limitations

While the diet-induced obesity model is a valuable tool in obesity research, it has some limitations. Not all animals fed a HFD develop obesity and metabolic disorders, reflecting the genetic and environmental factors that contribute to these conditions in humans. Furthermore, the model does not fully replicate the complex etiology of human obesity, which involves not only diet but also factors such as physical activity, sleep, and stress.

See also

• Obesity
• Metabolic syndrome
• High-fat diet
• Insulin resistance
• Type 2 diabetes
• Cardiovascular disease
• Non-alcoholic fatty liver disease

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